As of today, Deep Learning can be easily considered the hottest topic in the field of Artificial Intelligence.
Since 2018 Brevetti CEA embeds machine learning algorithms into the inspection machines software for particles detection, bubbles discrimination and cosmetic analysis.
Recently, in order to continue to improve the standards of inspection quality, Brevetti CEA acquired CRITERION AI, a Danish Company deeply specialized in image-based deep learning algorithms with an extensive experience in the pharmaceutical industry. The merger between the already existing Deep Learning Division of Brevetti CEA and the Team of experts of Criterion AI gave birth to BREVETTI AI, a Brevetti CEA company, fully dedicated to artificial intelligence applications and solutions.
Brevetti AI makes use of the latest advancements in deep learning to better classify, segment and detect anomalies in images; it leverages the power of deep learning to decrease false rejection and increase detection rates for pharmaceutical and medical devices.
Brevetti AI has designed a ready-to-use powerful platform to support deep learning workloads such as a data management, model training and validation. The platform complies with CFR 21 Part 11 and GMP Annex 11.
A new inspection era has started!
Container integrity has always been an extremely important topic in the Pharmaceutical
Industry as it represents one of the key factors for product's safety.
Brevetti CEA offers integrated and stand-alone leak testing solutions for liquid and freeze-dried pharmaceutical products based on different non-invasive, non-destructive testing methods:
High Voltage Leak Detection in Liquid (HV)
Head Space Gas Analyzer in Freeze-dried (HGA)
Based on TDLAS spectroscopic technology, the laser is modulated in frequency to assure a more accurate, stable and reliable measurement. Light absorption is proportional to oxygen concentration in the optical path.
The system can discern oxygen-free (good) containers from the ones contaminated by oxygen due to leakage or process fault.
The installation of HGA leak detection unit into an automatic inspection machine integrates the classic detection capabilities of visual inspection and it represents the state-of-the-art in terms of leak detection in products filled under low oxygen concentration or modified atmospheres (nitrogen).
O.D.M.S. device (Optical Density Measurement System) has been designed and manufactured in order to measure the turbidity of liquid products in transparent containers.
The system works using a non-invasive measurement method, suitable for turbidity analysis in ampoules, pre-filled syringes, cartridges and vials. The optical density measuring unit is composed of a laser module, a sensor head and an embedded processing unit.
The inspection is performed by measuring the optical density of the solution in each container using a laser beam gun and a receiving photodiode sensor.
Colour is a vital source of information for molecules and materials in general. It intimately depends on molecular structure and a little variation in molecules shape or composition could change their spectroscopic properties.
Oxidation, unwanted reactive contaminants in solution, thermal stress and UV degradation are some of the processes that could alter or damage a molecule.
The Spectrometer (Colour Analyzer) device measures a transmission spectrum for every analyzed container and compares it to a previously recorded reference one to detect possible product degradation and to implement anti-mix-up functions. The inspection is performed by a dedicated station which can be easily integrated in Brevetti C.E.A. inspection machines.
As a result of the continuous investments in research and development, Brevetti CEA has desgined an innovative automatic solution for the inspection of the so called “difficult to inspect” products, such as Cell Therapy products, IV Solutions Bags, Hyaluronic Acid, Albumin, Propofol, Iron sucrose etc.
This revolutionary concept merges the human into the automatic visual inspection, combining the advantages of motion and optics flexibility with the stability of inspection results. This allows the creation of a “humanlike” equipment with the possibility to vary the framing and to take advantage of the lighting sources that affect the image.
Thanks to a wide set of software tools, including a brand-new off-line setup mode to allow the parameters optimization phase completely off-line, the robot is a powerful system very easy to setup and validate.
Our efficient and technologically advanced automatic inspection machines can reach the speed of 800 pieces per minute on liquid products and 600 pieces per minute on freeze-dried products and syringes.
Given the complexity and sensitivity of most of the pharmaceutical products, all Brevetti CEA systems grant smooth mechanical handling throughout the process. The integration of sophisticated no-contact handling solutions permits a fully automatic cycle, including de-nesting and re-nesting activities on both glass and plastic syringes.